PTP4A1
Overview
PTP4A1 (Protein Tyrosine Phosphatase 4A1, also known as PRL-1) is a member of the PRL (phosphatase of regenerating liver) family of dual-specificity phosphatases implicated in cell proliferation and metastasis. In lung squamous cell carcinoma, PTP4A1 was identified as a novel focal amplification target by GISTIC2.0 analysis.
Alterations observed in the corpus
- PTP4A1 identified as a novel focal amplification target gene in lung SqCC in the 1,144-tumor NSCLC landscape study (660 lung ADC, 484 lung SqCC); co-amplified with PHF3 at the same focal GISTIC2.0 peak. PMID:27158780
Cancer types (linked)
- LUSC: PTP4A1/PHF3 locus is a novel focal amplification peak identified specifically in lung squamous cell carcinoma. PMID:27158780
Co-occurrence and mutual exclusivity
- Co-amplified with PHF3 at the same focal GISTIC2.0 peak in lung SqCC. PMID:27158780
Therapeutic relevance
- PRL family phosphatases have been proposed as oncology targets due to their roles in cell proliferation and invasion, but no clinical therapeutic data relevant to the lung SqCC amplification are available in the corpus.
Open questions
- Whether PTP4A1 or PHF3 is the functional driver of the focal amplification peak in lung SqCC has not been resolved.
Sources
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