PIK3C3

Overview

One-paragraph summary of the gene’s role and why it matters in cancer genomics.

Alterations observed in the corpus

• Mutation classes (missense / truncating / fusion / amplification / deletion) with links to the papers that report them.
• Frequently mutated in LUAD (TSP, n=188); co-mutates with PTPRD; part of mTOR pathway alteration in >30% of tumours. PMID:18948947
• PIK3C3 mutated as part of the PI3K/AKT/mTOR pathway, disrupted in 39% ATC vs 11% PDTC (P=1×10⁻³) in a targeted-sequencing study of advanced thyroid cancers. PMID:26878173

Cancer types (linked)

• Per cancer type: prevalence, co-mutation patterns, clinical significance.

Co-occurrence and mutual exclusivity

• Linked partner genes with the relationship and the paper(s) reporting it.

Therapeutic relevance

• Drugs (linked) targeting this gene or its pathway, with the studies supporting them.

Open questions

• Conflicts or unresolved findings across papers.

Sources

This page was processed by crosslinker on 2026-05-05. - PMID:18948947

This page was processed by crosslinker on 2026-05-05. - PMID:26878173

This page was processed by wiki-cli on 2026-05-14.