PLCG1
Overview
PLCG1 (phospholipase C gamma 1) encodes a signaling enzyme involved in receptor tyrosine kinase pathways. PLCG1 mutations have been identified in radiation-associated angiosarcoma, where they may contribute to aberrant vascular signaling.
Alterations observed in the corpus
- PLCG1 mutations were identified in RT-AS in a whole-genome sequencing study of radiation-associated secondary malignancies; PLCG1 mutations were found alongside PTPRB mutations in RT-AS driver landscapes PMID:37350195.
- Three point mutations in Sézary syndrome: novel p.Gly722Val and previously reported gain-of-function alleles p.Arg48Trp and p.Glu1163Lys PMID:26551667
Cancer types (linked)
- ANGS – PLCG1 mutations reported in RT-associated angiosarcoma PMID:37350195.
Co-occurrence and mutual exclusivity
- PLCG1 mutations co-occur with PTPRB mutations in RT-AS PMID:37350195.
Therapeutic relevance
- No PLCG1-directed therapy is reported in this corpus PMID:37350195.
Open questions
- The prevalence and functional significance of PLCG1 mutations in RT-AS vs sporadic AS has not been fully characterized in the MSK-IMPACT cohort PMID:37350195.
Sources
This page was processed by entity-page-writer on 2026-04-10. - PMID:26551667
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