PTPRB
Overview
PTPRB (protein tyrosine phosphatase receptor type B) encodes a receptor-type phosphatase expressed in vascular endothelium. In angiosarcoma, PTPRB mutations are recurrent and may contribute to oncogenesis through loss of phosphatase-mediated growth suppression.
Alterations observed in the corpus
- PTPRB mutations were identified in RT-AS in a whole-genome sequencing study; among RT-AS, PTPRB mutations were found only in tumors that were either known to be secondary to radiation therapy and/or had MYC amplification (p = 0.005), with a prevalence of 45% in this subgroup PMID:37350195.
Cancer types (linked)
- ANGS – PTPRB mutations enriched in RT-AS with MYC amplification or confirmed radiation-associated origin; 45% prevalence in this subgroup PMID:37350195.
Co-occurrence and mutual exclusivity
- PTPRB mutations co-occur with MYC amplification in RT-AS (p = 0.005) and co-occur with PLCG1 mutations in the RT-AS driver landscape PMID:37350195.
Therapeutic relevance
- No PTPRB-directed therapy is reported in this corpus PMID:37350195.
Open questions
- Whether PTPRB mutation status can serve as a biomarker distinguishing radiation-associated from sporadic angiosarcoma warrants further investigation PMID:37350195.
Sources
This page was processed by crosslinker on 2026-04-10.