PLK1

Overview

PLK1 (Polo-Like Kinase 1) is a serine/threonine kinase that plays a central role in mitotic entry, spindle assembly, and cytokinesis. It is frequently overexpressed in cancer and is a therapeutic target under active investigation.

Alterations observed in the corpus

  • Target oncogene with increased expression in HNSCC tumors driven by deletion/decreased levels of let-7c-5p and miR-100-5p; co-regulated alongside CDK6, E2F1, and HMGA2 via this miRNA network PMID:25631445

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

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