PTPN1

Overview

PTPN1 (PTP1B) is a tyrosine phosphatase and negative regulator of JAK/STAT signaling. In the corpus it is a classic Hodgkin lymphoma driver and one of the temporally earliest pathogenic events in cHL.

Alterations observed in the corpus

  • Mutated in 8% of classic Hodgkin lymphoma cases across 61 WGS/WES-profiled patients PMID:36723991.
  • Evolutionary timing analysis placed PTPN1 driver mutations (together with B2M, BCL7A, GNA13) before large chromosomal gains and whole-genome duplication, making it an early event in cHL pathogenesis PMID:36723991.

Cancer types (linked)

  • Classic Hodgkin lymphoma (CHL) — 8% mutation frequency; early driver PMID:36723991.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic link reported in the corpus.

Open questions

  • How early PTPN1 events in cHL relate to equivalent early events in DLBCL and other AID-driven B-cell lymphomas PMID:36723991.

Sources

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