BCL7A

Overview

BCL7A is a SWI/SNF-associated gene recurrently mutated in B-cell lymphomas, where AID-mediated off-target mutagenesis generates non-coding and coding lesions.

Alterations observed in the corpus

  • Mutated in 18% of classic Hodgkin lymphoma cases in the 61-patient WGS+WES cohort PMID:36723991.
  • Showed an elevated noncoding-to-coding mutation ratio consistent with AID off-target activity, along with SOCS1, TMSB4X, IL4R, and ITPKB PMID:36723991.
  • Timed as an early event in cHL pathogenesis, preceding whole-genome duplication and large chromosomal gains PMID:36723991.
  • Recurrent translocation involving BCL7A detected by low-pass WGS in 5/106 endometrial carcinoma tumors (ucec_tcga_pub); predicted in-frame fusions with increased BCL-family expression PMID:23636398
  • Implicated in one or two PCNSL cases as part of focal amplification or homozygous deletion events in genome-wide analysis of 18 PCNSL samples PMID:25991819

Cancer types (linked)

  • Classic Hodgkin lymphoma — BCL7A is among the eight driver genes newly described in cHL by the WGS HRS-cell study PMID:36723991.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct BCL7A-targeted therapy is reported in the corpus PMID:36723991.

Open questions

  • Functional consequences of BCL7A mutation in HRS cells, and whether the noncoding AID footprint changes expression, are not resolved PMID:36723991.

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:23636398

This page was processed by crosslinker on 2026-05-14. - PMID:25991819

This page was processed by crosslinker on 2026-05-14.