PTPRS
Overview
PTPRS (Protein Tyrosine Phosphatase Receptor Type S) encodes a receptor-type protein tyrosine phosphatase involved in cell adhesion and axon guidance. In cancer genomics, PTPRS has been identified as a recurrently mutated gene in colorectal cancer, particularly in the microsatellite-stable (MSS) subtype, where it represents a newly characterized driver candidate alongside other low-frequency recurrent alterations.
Alterations observed in the corpus
- Identified as a novel recurrently mutated gene (1–4% frequency) in MSS metastatic colorectal cancer by MSK-IMPACT targeted sequencing of 1,134 colorectal adenocarcinomas PMID:29316426
Cancer types (linked)
- COAD: Recurrent mutations detected in MSS metastatic colorectal cancer cohort (1–4% frequency) PMID:29316426
Co-occurrence and mutual exclusivity
Therapeutic relevance
- No specific therapeutic relevance established in the corpus; PTPRS mutations in MSS mCRC represent novel driver candidates whose actionability has not yet been defined.
Open questions
- The functional consequence of PTPRS mutations in colorectal cancer (tumor suppressor vs. passenger) has not been established in this corpus.
- Whether PTPRS mutations confer any prognostic or predictive value in mCRC requires further study.
Sources
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