RAD51C
Overview
RAD51C encodes a member of the RAD51 family of proteins involved in homologous recombination (HR) DNA repair. Germline mutations in RAD51C are associated with increased risk of ovarian and breast cancer. In high-grade serous ovarian carcinoma (HGSOC), RAD51C mutations contribute to the HR deficiency that characterizes this tumor type.
Alterations observed in the corpus
- Mutated in high-grade serous ovarian carcinoma (HGSOC) identified in TCGA integrated genomic analysis of 489 tumors PMID:21720365
- In mCRPC, RAD51C was among the broader DNA-repair/recombination pathway alterations contributing to the 22.7% aggregate in the SU2C–PCF 150-case cohort. PMID:26000489
- Focal DNA losses in 3% of primary prostate tumors, mostly heterozygous; included among DNA-repair gene defects (totaling ~19%) relevant to PARP inhibitor sensitivity PMID:26544944
- F8L variant in osteosarcoma (OS); identified as a PARP-inhibitor target in a pediatric precision-oncology program (n=101 high-risk patients) PMID:28007021
Cancer types (linked)
- High-grade serous ovarian carcinoma (OV): somatic mutations contributing to homologous recombination deficiency PMID:21720365
Co-occurrence and mutual exclusivity
- Part of the broader homologous recombination deficiency landscape in HGSOC alongside BRCA1, BRCA2, and other HR pathway genes PMID:21720365
Therapeutic relevance
- HR deficiency caused by RAD51C mutations may confer sensitivity to PARP inhibitors and platinum-based chemotherapy PMID:21720365
Open questions
- Relative frequency and clinical significance of RAD51C mutations in HGSOC compared to BRCA1/BRCA2 mutations remains to be fully characterized.
Sources
This page was processed by crosslinker on 2026-05-14. - PMID:26000489
This page was processed by crosslinker on 2026-05-14. - PMID:26544944
This page was processed by wiki-cli on 2026-05-14. - PMID:28007021
This page was processed by wiki-cli on 2026-05-14.