SHQ1

Overview

SHQ1 encodes an H/ACA ribonucleoprotein assembly factor involved in pseudouridylation of rRNA and snRNA. Located at 3p14, SHQ1 is a candidate tumor suppressor in prostate cancer, with both deletion and somatic point mutations observed in the MSKCC cohort.

Alterations observed in the corpus

  • Deletion at 3p14 and somatic P22S mutation identified as a candidate tumor suppressor in integrative genomic profiling of 218 prostate cancer tumors PMID:20579941
  • Co-deleted with FOXP1 and RYBP in a focal 3p13 deletion identified by aCGH and low-pass WGS of FFPE prostatectomy needle biopsies (prad_mskcc_2014 proof-of-principle). PMID:25024180
  • Part of 3p21 focal heterozygous deletion (co-deleted with RYBP and FOXP1) in MSK-PCa1 and MSK-PCa7 prostate cancer cell lines PMID:25201530
  • Part of the complex 3p13 deletion locus involving FOXP1/RYBP/SHQ1 in primary prostate cancer PMID:26544944

Cancer types (linked)

  • Prostate adenocarcinoma (PRAD): recurrent deletion at 3p14, with at least one tumor also carrying a somatic P22S point mutation PMID:20579941

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic targeting currently described.

Open questions

  • Functional role of SHQ1 as a driver tumor suppressor at 3p14 requires experimental validation; the somatic P22S mutation significance is unknown.

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:25024180

This page was processed by crosslinker on 2026-05-14. - PMID:25201530

This page was processed by crosslinker on 2026-05-14. - PMID:26544944

This page was processed by crosslinker on 2026-05-14.