SLITRK6
Overview
SLITRK6 encodes a transmembrane protein of the SLITRK (SLIT and NTRK-like) family involved in synaptogenesis and neural development. Its role in cancer is not well characterized; it has been identified as a significantly mutated gene (SMG) in kidney renal clear cell carcinoma (KIRC) in pan-cancer calling studies, though its function as a driver versus passenger remains unclear due to the large size of the gene potentially inflating mutation rates.
Alterations observed in the corpus
- Called as a KIRC SMG uniquely by MuSiC2 (after long-gene filtering) in the TCGA MC3 pan-cancer mutation calling study; not recovered by MutSig2CV, illustrating caller-specific gene discovery PMID:29596782
Cancer types (linked)
- Kidney renal clear cell carcinoma (KIRC): identified as SMG by MuSiC2 in TCGA MC3 analysis PMID:29596782
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- Whether SLITRK6 is a true driver in KIRC or a passenger with inflated mutation rate due to gene length remains unresolved PMID:29596782
Sources
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