SOX10

Overview

SOX10 (SRY-Box Transcription Factor 10) is a high-mobility-group transcription factor that is a master regulator of neural crest cell development and a canonical marker of Schwann cell precursors (SCPs). In neuroblastoma biology, SOX10 is used to define the SCP compartment in the adrenal gland; its absence from the novel hC1 progenitor cluster demonstrates that hC1 is distinct from classical SCPs.

Alterations observed in the corpus

  • SOX10 is a canonical Schwann cell precursor (SCP) marker absent from the novel hC1 progenitor cluster in postnatal human adrenal gland (FDR <0.01); RNAscope ISH confirmed SOX10+ cells in the adrenal gland are distinct from NTRK2+/CLDN11+ hC1 cells at all ages (0 y, 4 y, adult). The hC1 cluster lacks SOX10, FOXD3, and S100B expression, distinguishing it from mouse and human embryonic SCPs. PMID:34493726
  • CCLE pharmacogenomic profiling (947 cell lines, 24 drugs) identified SOX10 expression as a marker in neural crest-derived cancer cell lines relevant to drug sensitivity predictions PMID:22460905

Cancer types (linked)

  • NBL — SOX10 marks the SCP compartment in the adrenal gland and in previous SCP-based neuroblastoma cell-of-origin models; its absence from the hC1 progenitor and the high-risk nC3 tumor cluster argues that high-risk neuroblastoma does not arise from classical SOX10+ SCPs. PMID:34493726

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic role for SOX10 is reported in this corpus. Its value is primarily as a negative marker distinguishing SCP from the postulated high-risk neuroblastoma progenitor.

Open questions

  • Whether SOX10+ SCP cells in the adrenal gland contribute to any neuroblastoma subtype remains an open question not resolved by this study. PMID:34493726

Sources

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