CLDN11
Overview
CLDN11 (claudin-11, also known as oligodendrocyte-specific protein/OSP) is a tight junction component expressed in oligodendrocytes and other neural cell types. In neuroblastoma, CLDN11 is part of the progenitor/migratory gene program shared between the postnatal human adrenal progenitor cluster and high-risk undifferentiated tumor cells.
Alterations observed in the corpus
- CLDN11 is part of the progenitor/migratory gene program shared between the normal postnatal human adrenal progenitor cluster (hC1) and the undifferentiated high-risk neuroblastoma cluster (nC3), alongside BCL11A, ASXL3, ERBB3, RTTN, TP63, POU6F2, SOX6, and DOCK7; identified by single-nuclei RNA-seq of 11 neuroblastoma tumors PMID:34493726.
- The authors specifically note that the TRKB+/CLDN11+ cholinergic progenitor signature could represent the cell of origin for high-risk neuroblastoma in older children PMID:34493726.
Cancer types (linked)
- Neuroblastoma (NBL) — CLDN11 marks the high-risk undifferentiated nC3 cluster enriched for MYCN-amplified and/or 11q-deleted tumors; the TRKB+/CLDN11+ signature stratifies survival in 498 SEQC patients (Kaplan-Meier, Bonferroni-corrected p < 0.01) PMID:34493726.
Co-occurrence and mutual exclusivity
Therapeutic relevance
- Not directly therapeutically targeted in the corpus; identified as a prognostic signature component with potential utility as a transcriptomic biomarker for high-risk neuroblastoma PMID:34493726.
Open questions
- Whether CLDN11 is functionally required for the undifferentiated state of nC3 cells, or serves purely as a marker of a shared progenitor identity, is not tested in the corpus.
Sources
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