SPOPL
Overview
SPOPL (Speckle-type POZ Protein-Like) is a paralog of SPOP, encoding a BTB-domain-containing substrate adaptor for the CUL3 ubiquitin ligase complex. In prostate cancer, SPOPL undergoes recurrent focal deletion, suggesting a tumor-suppressive function analogous to SPOP.
Alterations observed in the corpus
- Recurrent focal deletion at 2q22.1 in primary prostate cancer (PRAD); identified in the TCGA molecular taxonomy as a significantly deleted locus PMID:26544944
Cancer types (linked)
- PRAD: Recurrent focal deletion at 2q22.1 observed in the TCGA prostate cancer cohort PMID:26544944
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- Whether SPOPL deletion is functionally equivalent to SPOP mutation in prostate cancer remains uncharacterized.
Sources
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