STAT6
Overview
STAT6 is a JAK/STAT pathway transcription factor recurrently mutated in classic Hodgkin lymphoma.
Alterations observed in the corpus
- STAT6 was mutated in 20% of classic Hodgkin lymphoma cases, placing it among the top drivers identified by WGS/WES PMID:36723991.
- WES of 55 DLBCL tumors identified recurrent STAT6 mutations, implicating IL-4/IL-13 signaling dysregulation in diffuse large B-cell lymphoma pathogenesis PMID:22343534
- Preferentially mutated in GCB DLBCL PMID:28985567
Cancer types (linked)
- CHL — 20% mutated; JAK/STAT pathway driver PMID:36723991.
Co-occurrence and mutual exclusivity
- Part of the JAK/STAT driver set in cHL alongside SOCS1 PMID:36723991.
Therapeutic relevance
- No direct targeted therapy reported in the corpus.
Open questions
- None specific to STAT6 in the corpus.
Sources
This page was processed by crosslinker on 2026-04-08. - PMID:22343534
This page was processed by wiki-cli on 2026-05-06. - PMID:28985567
This page was processed by wiki-cli on 2026-05-15.