TCF7

Overview

TCF7 (Transcription Factor 7), also known as TCF-1, encodes a T-cell-specific transcription factor in the HMG-box family and is a key effector of canonical WNT/beta-catenin signaling. TCF7 interacts with beta-catenin to regulate WNT target gene expression. It has a dual role in cancer: as a WNT effector its mutations may dysregulate WNT signaling in colorectal cancer, and in the immune compartment it marks stem-like CD8+ T cells.

Alterations observed in the corpus

  • Newly significant colorectal cancer (CRC) driver in the WNT pathway, identified in a large CRC exome-sequencing and neoantigen analysis of 619 cases PMID:27149842.

Cancer types (linked)

  • COAD / Colorectal cancer: Newly nominated as a significantly mutated WNT-pathway driver gene PMID:27149842.

Co-occurrence and mutual exclusivity

  • Co-nominated as a CRC driver alongside BCL9L in the same WNT-pathway gene class PMID:27149842.

Therapeutic relevance

  • WNT-pathway mutations in CRC have broad implications for cancer biology; specific therapeutic relevance of TCF7 mutations was not addressed in the citing study PMID:27149842.

Open questions

  • Whether TCF7 mutations in CRC are gain-of-function (WNT activating) or loss-of-function (disrupting WNT target gene selectivity) was not determined in the citing study PMID:27149842.

Sources

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