TNFRSF10A
Overview
TNFRSF10A (TNF Receptor Superfamily Member 10A), also known as DR4 or TRAIL-R1, is a death receptor that mediates apoptosis in response to TRAIL. It was identified as implicated in focal amplification or homozygous deletion events in primary central nervous system lymphoma (PCNSL).
Alterations observed in the corpus
- Implicated in one or two cases as part of focal amplification or homozygous deletion events in primary central nervous system lymphoma (PCNSL). PMID:25991819
Cancer types (linked)
- PCNSL: Rare focal CNA; part of the genomic landscape identified by genome-wide analysis (N=18 aCGH, N=10 WES). PMID:25991819
Co-occurrence and mutual exclusivity
- No specific co-occurrence or mutual exclusivity patterns reported in the corpus.
Therapeutic relevance
- TRAIL-based therapies targeting DR4 have been investigated in lymphomas; relevance of TNFRSF10A alterations in PCNSL context is unexplored.
Open questions
- Low recurrence (1-2 cases) limits conclusions about TNFRSF10A as a driver in PCNSL; functional validation required. PMID:25991819
Sources
This page was processed by crosslinker on 2026-05-14.