TRAF2
Overview
TRAF2 (TNF Receptor Associated Factor 2) is an adapter protein in the NF-kB signaling pathway that mediates anti-apoptotic signals downstream of TNFR family receptors. Recurrent mutations in TRAF2 were identified as a novel B-cell activity driver in CLL in a large-scale whole-exome sequencing study, consistent with its known role in regulating B-cell survival.
Alterations observed in the corpus
- Identified as a novel B-cell activity driver in CLL in a 538-patient WES study (CLL8 trial cohort); mutations disrupt NF-kB signaling regulation PMID:26466571
Cancer types (linked)
- CLLSLL — Recurrent driver mutation in a NF-kB pathway gene; co-reported with TRAF3 and CARD11 as B-cell activity drivers PMID:26466571
Co-occurrence and mutual exclusivity
- Co-reported with TRAF3 and CARD11 as a group of B-cell activity drivers in CLL PMID:26466571
Therapeutic relevance
- NF-kB pathway activation via TRAF2 mutation may confer sensitivity to NF-kB inhibition strategies; no specific drug claims reported in this dataset PMID:26466571
Open questions
- Precise functional consequences of TRAF2 mutations in CLL and their interaction with other NF-kB pathway alterations require further study PMID:26466571
Sources
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