UBA7

Overview

UBA7 encodes an E1 ubiquitin-activating enzyme specific for the ubiquitin-like modifier ISG15. Located on chromosome 3p, UBA7 is subject to cis down-regulation upon chr_3p deletion. Paradoxically, UBA7 was found to be up-regulated in early-passage 3p-deleted AALE lung epithelial cells, consistent with interferon (IFN) pathway activation observed by GSEA in the context of chromosomal instability. This transient up-regulation was not sustained at later passages.

Alterations observed in the corpus

• 3p-encoded E1 ubiquitin enzyme that targets ISG15; up-regulated greater than 2-fold in early-passage chr_3p-deleted AALE clones but not at later passage, consistent with transient IFN-pathway activation in response to chromosome arm loss PMID:29622463

Cancer types (linked)

• Pan-cancer: located on 3p, subject to deletion in squamous cancers and other tumor types with 3p loss PMID:29622463

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

• Why UBA7 is transiently up-regulated (rather than down-regulated) after 3p deletion in early-passage cells, and what the IFN-pathway activation implies for immune microenvironment in 3p-deleted tumors, remains to be fully characterized PMID:29622463

Sources

• PMID:29622463

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