ISG15
Overview
ISG15 encodes a ubiquitin-like protein that is robustly induced by type I interferons and plays roles in innate immune defense. In HGSOC, ISG15 is among the earliest upregulated IFN-stimulated genes in precursor lesions.
Alterations observed in the corpus
- ISG15 is an IFN-stimulated gene upregulated early in HGSOC development beginning at the p53 signature stage; part of an IFN-alpha and IFN-gamma pathway gene upregulation program also including STAT1, IFITM1, IRF7, IRF9, TAP1, and HLA-A PMID:39386723.
- ISG15 encodes an interferon-stimulated ubiquitin-like modifier that is targeted by UBA7 (a 3p-encoded E1 ubiquitin enzyme); UBA7 is up-regulated greater-than 2-fold in early-passage cells with engineered chromosome 3p deletion, consistent with IFN-pathway up-regulation observed by GSEA after 3p loss. PMID:29622463
Cancer types (linked)
- HGSOC — upregulated in fallopian tube precursor lesions (p53 signatures, STICs) and invasive cancer; studied by GeoMx spatial transcriptomics on 44 specimens from 43 individuals PMID:39386723.
Co-occurrence and mutual exclusivity
Therapeutic relevance
- Early IFN pathway activation including ISG15 in HGSOC precursors could serve as a biomarker panel for risk stratification of high-risk patients PMID:39386723.
Open questions
- Whether ISG15 has a direct functional role (e.g., via ISGylation of target proteins) in shaping the HGSOC immune microenvironment is unresolved PMID:39386723.
Sources
This page was processed by crosslinker on 2026-05-04. - PMID:29622463
This page was processed by wiki-cli on 2026-05-15.