UHRF2
Overview
UHRF2 (Ubiquitin-Like With PHD And Ring Finger Domains 2) is an E3 ubiquitin ligase involved in DNA methylation maintenance and cell cycle regulation. It has prior reports in colon-cancer cell growth and survival. In periampullary adenocarcinoma, UHRF2 expression is co-regulated with the neighboring KDM4C histone demethylase through a shared promoter/5’ chromosomal deletion.
Alterations observed in the corpus
- UHRF2 expression co-reduced with KDM4C through a focal chromosome-9 deletion removing the promoter/5’ end of KDM4C in ampullary adenocarcinoma (AMPAC); deletion is statistically significant in AMPAC and lowers expression of both genes PMID:26804919
Cancer types (linked)
- Ampullary adenocarcinoma (AMPAC): UHRF2 co-deleted with KDM4C via focal 9p deletion; both have prior reports in colon-cancer biology PMID:26804919
Co-occurrence and mutual exclusivity
- UHRF2 co-deletion occurs with KDM4C in the same focal 9p deletion event in periampullary tumors; KDM4C complexes with beta-catenin, linking this deletion to WNT pathway biology PMID:26804919
Therapeutic relevance
- No direct therapeutic targeting of UHRF2 reported in the corpus.
Open questions
- Whether UHRF2 loss independently contributes to periampullary tumor biology or is a co-deleted passenger alongside KDM4C remains unresolved PMID:26804919
Sources
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