USP28

Overview

USP28 (ubiquitin-specific peptidase 28) is a deubiquitinase that regulates protein stability for several substrates including MYC, JUN, and 53BP1. It has been identified as a significantly mutated gene in prostate cancer, placing it within the ubiquitin-pathway SMG cluster alongside USP7 in the SU2C/PCF 1,013-sample cohort.

Alterations observed in the corpus

• Identified as a ubiquitin-pathway SMG in a 1,013-sample prostate cancer cohort (discovery + MSK-IMPACT validation); co-nominated with USP7 as a novel driver in the ubiquitin pathway PMID:29610475

Cancer types (linked)

• Prostate cancer (PRAD): ubiquitin-pathway SMG in SU2C/PCF 1,013-sample cohort PMID:29610475

Co-occurrence and mutual exclusivity

• Co-nominated with USP7 as ubiquitin-pathway SMGs in prostate cancer PMID:29610475

Therapeutic relevance

Open questions

Sources

• PMID:29610475

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