USP7
Overview
USP7 (ubiquitin-specific peptidase 7, also known as HAUSP) is a deubiquitinase that stabilizes MDM2 and TP53, playing a central role in the p53 pathway. It has been identified as a significantly mutated gene in prostate cancer, placing it in the ubiquitin-pathway SMG cluster alongside USP28 in the SU2C/PCF 1,013-sample cohort.
Alterations observed in the corpus
- Identified as a ubiquitin-pathway SMG in a 1,013-sample prostate cancer cohort (discovery + MSK-IMPACT validation); co-nominated with USP28 as a novel driver in the ubiquitin pathway PMID:29610475
Cancer types (linked)
- Prostate cancer (PRAD): ubiquitin-pathway SMG in SU2C/PCF 1,013-sample cohort PMID:29610475
Co-occurrence and mutual exclusivity
- Co-nominated with USP28 as ubiquitin-pathway SMGs in prostate cancer PMID:29610475
Therapeutic relevance
- USP7 inhibition is being explored as a therapeutic strategy to destabilize MDM2 and restore TP53 activity; identification as an SMG in prostate cancer adds context for its targeting in that disease PMID:29610475
Open questions
Sources
This page was processed by crosslinker on 2026-05-15.