CREST

Overview

CREST (Clipping REveals STructure) is a structural variant detection algorithm that uses soft-clipped reads from short-read sequencing alignments to identify genomic rearrangements including translocations, inversions, and insertions at single-nucleotide resolution.

Used by

• Applied in 60-sample ACC study (55 WES + 5 WGS) for structural variant detection alongside MuTect and SomaticSniper; contributed to characterization of MYB-NFIB translocations and other somatic rearrangements PMID:23685749
• Used in ICGC PedBrain pilocytic astrocytoma WGS study (96 cases) alongside pindel and delly for SV detection; identified novel BRAF fusion partners and NTRK2 fusions PMID:23817572
• Used for structural-variant calling in Ewing sarcoma WGS (112 tumors); STAG2 mutations correlated with elevated SV count detected by CREST PMID:25223734
• Used to detect structural variants in 71 WGS CCA tumor/normal pairs, identifying ~93 somatic SVs per tumor (median 69, range 0–395); 91% of SVs were PCR-validated PMID:28667006

Notes

• Corpus-grown slug; not found in cBioPortal canonical gene panel ontology.
• Commonly used with DELLY and Pindel in complementary SV calling pipelines.

Sources

This page was processed by entity-page-writer on 2026-05-11. - PMID:25223734

This page was processed by entity-page-writer on 2026-05-11. - PMID:28667006

This page was processed by wiki-cli on 2026-05-15.