DELLY

Overview

DELLY is a structural variant detection tool that discovers deletions, tandem duplications, inversions, and translocations in paired-end short-read sequencing data by combining paired-end mapping and split-read analysis. It is designed for both germline and somatic structural variant discovery.

Used by

• Used in ICGC PedBrain pilocytic astrocytoma WGS study (96 cases, hg19) alongside pindel and crest for somatic SV detection; helped identify the full spectrum of MAPK-pathway rearrangements including novel BRAF fusions PMID:23817572
• DELLY used for structural variant detection in targeted sequencing of pancreatic cancer PMID:26278805
• Used DELLY to detect structural variants including deletions, duplications, and inversions from sequencing data PMID:28445112
• Delly v0.6.1 used for structural variant detection in the MSK-IMPACT bioinformatics pipeline across 10,945 tumors, identifying 1,875 rearrangements including 268 kinase fusions PMID:28481359

Notes

• Corpus-grown slug; not found in cBioPortal canonical gene panel ontology.
• Commonly used in ensemble SV-calling pipelines with CREST and Pindel.

Sources

This page was processed by crosslinker on 2026-05-09. - PMID:26278805

This page was processed by wiki-cli on 2026-05-14. - PMID:28445112

This page was processed by wiki-cli on 2026-05-14. - PMID:28481359

This page was processed by wiki-cli on 2026-05-15.