ARHGEF3

Overview

ARHGEF3 (Rho Guanine Nucleotide Exchange Factor 3) encodes a guanine nucleotide exchange factor (GEF) that activates RhoA and RhoB GTPases. In the cancer genomics corpus, ARHGEF3 has been identified as somatically mutated in adenoid cystic carcinoma (ACYC) as part of a broader Rho-pathway disruption that also includes recurrent RHOA mutations — the first reported in ACYC.

Alterations observed in the corpus

• Somatic Rho-GEF mutation identified in adenoid cystic carcinoma (ACYC), part of a broader Rho-pathway disruption alongside RHOA mutations present in 2 tumours PMID:26862087

Cancer types (linked)

• ACYC (Adenoid Cystic Carcinoma): ARHGEF3 was among multiple Rho-pathway genes somatically mutated in a 25-tumour WGS cohort; Rho pathway targeting is proposed as a candidate therapeutic strategy in ACYC PMID:26862087

Co-occurrence and mutual exclusivity

• Co-mutated with other Rho-pathway genes (ARHGEF5, ARHGEF18, RHOA, CDH2, CDH13, ACTB) in ACYC PMID:26862087

Therapeutic relevance

• Rho-pathway inhibition flagged as a candidate therapeutic strategy for ACYC, leveraging existing precision-anticancer Rho-targeting research PMID:26862087

Open questions

• Functional consequence of ARHGEF3 mutation in ACYC not characterised; therapeutic implications are speculative and require functional/in vivo validation PMID:26862087

Sources

• PMID:26862087

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