CDH2
Overview
CDH2 (cadherin 2, also known as N-cadherin) encodes a calcium-dependent cell adhesion molecule involved in epithelial-mesenchymal transition and cell migration. In cancer genomics, CDH2 has been identified as a candidate tumor suppressor gene in desmoplastic melanoma based on loss-of-function mutation burden analysis.
Alterations observed in the corpus
- Identified as a LOF-burden tumor-suppressor candidate in desmoplastic melanoma exome sequencing (n=60 discovery + 42 validation samples); listed alongside FSIP1, IL36A, and PAK3 as additional LOF-burden TS candidates PMID:26343386
- Mentioned in study PMID:26862087
Cancer types (linked)
- DESM / MEL: LOF-burden candidate tumor suppressor in desmoplastic melanoma; specific mutation frequency not reported separately PMID:26343386
Co-occurrence and mutual exclusivity
Therapeutic relevance
- No direct therapeutic associations identified in this corpus.
Open questions
- Functional significance of CDH2 as a tumor suppressor in desmoplastic melanoma requires experimental validation PMID:26343386
Sources
This page was processed by crosslinker on 2026-05-14. - PMID:26862087
This page was processed by wiki-cli on 2026-05-14.