BIRC3

Overview

BIRC3 (baculoviral IAP repeat-containing 3, also known as cIAP2) is an IAP family member that inhibits caspase-mediated apoptosis. In OSCC, BIRC3 is located within or near the 11q13 CCND1 amplicon and exhibits copy number gain with strong CN-expression correlation.

Alterations observed in the corpus

  • Located within or near the 11q13 CCND1 amplicon in OSCC; copy-number gain with strong CN-expression correlation; co-amplified alongside BIRC2, FADD, IKBKB, and CCND1 in the 22% of OSCC tumors with 11q13 focal amplification. PMID:23619168
  • Exon-9 inactivating and splice-site mutations in 11/173 (6.4%) mantle cell lymphoma (MCL); tightly co-occurs with 11q22.2 deletion (10/11 vs 25/87, P=1.1×10⁻⁴); can be acquired post-treatment, consistent with chemotherapy-driven clonal selection at relapse PMID:24145436
  • Within a recurrent significant homozygous-deletion peak in multiple myeloma (MM); co-deleted with BIRC2 as part of the NF-kB pathway regulatory locus; recurrent homozygous deletions at this locus identified by GISTIC across 153 MM patients PMID:24434212
  • Inhibitor-of-apoptosis protein cIAP2; targeted by tolinapant + radiotherapy in NPC PMID:24952746
  • BIRC3 enriched in prior-treatment CLL samples; co-occurs with tri(12); copy loss precedes sSNV/sINDEL in biallelic inactivation; did not replicate as a PFS predictor in the CLL8 trial (frontline fludarabine-based chemoimmunotherapy, n=278) PMID:26466571

Cancer types (linked)

  • OCSC / HNSC: co-amplification at 11q13 locus in OSCC; CCND1 amplification (22% of OSCC, 8/38) is the anchor of this amplicon. PMID:23619168

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • BIRC3/cIAP2 is a target of SMAC mimetics; co-amplification at 11q13 may confer resistance to apoptotic stimuli in OSCC. PMID:23619168

Open questions

  • Functional driver status of BIRC3 copy gain in OSCC versus co-amplification with CCND1 as a passenger remains unresolved. PMID:23619168

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:24145436

This page was processed by crosslinker on 2026-05-14. - PMID:24434212

This page was processed by crosslinker on 2026-05-14. - PMID:24952746

This page was processed by crosslinker on 2026-05-14. - PMID:26466571

This page was processed by crosslinker on 2026-05-14.