CCNE2

Overview

CCNE2 encodes cyclin E2, a regulatory subunit of cyclin-dependent kinase 2 (CDK2) that promotes cell-cycle G1/S transition. Focal amplification of CCNE2 is a recurrent event in glioblastoma and other cancers, contributing to dysregulation of the Rb pathway and unchecked cellular proliferation.

Alterations observed in the corpus

Cancer types (linked)

  • GBM: recurrent focal amplification as part of the broader Rb-pathway dysregulation landscape (78.9% of GBM overall) PMID:24120142

Co-occurrence and mutual exclusivity

  • Co-amplified with CCND1 and CCND2 in GBM in a subtype-correlated pattern PMID:24120142

Therapeutic relevance

  • CDK2 inhibitors are a potential strategy in tumors with CCNE2 amplification, though no direct drug data are reported in the current corpus.

Open questions

  • Functional distinction between CCNE1 and CCNE2 amplification in GBM is not resolved in the current corpus.

Sources

This page was processed by crosslinker on 2026-05-09. - PMID:29100075

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