CCND2

Overview

CCND2 (cyclin D2) is a D-type cyclin that promotes G1/S cell cycle progression. In oligodendroglioma, CCND2 marks the stem/progenitor tumor compartment and undergoes a cyclin-switching transition as tumor cells differentiate — shifting from CCND2 to CCND1/CCND3 in differentiated cells, mirroring normal neural development.

Alterations observed in the corpus

  • CCND2 is part of the stem/progenitor transcriptional program in grade II IDH-mutant 1p/19q-codeleted oligodendroglioma, alongside SOX2, ASCL1, CHD7, CD24, BOC, NFIB, and SOX4/SOX11; identified from scRNA-seq of 4,347 cells across 6 tumors PMID:27806376.
  • Cyclin switching: CCND2 predominates in stem/progenitor cells, while CCND1 and CCND3 predominate in differentiated oligo-like and astro-like tumor cells PMID:27806376.
  • Recurrent focal amplification in GBM; subtype-correlated alongside CCND1 and CCNE2 PMID:24120142
  • Low-frequency (1.4%) cell-cycle hit in rhabdomyosarcoma (RMS); part of mitotic-checkpoint/cell-cycle gene group with CCND1, BUB1B, and FOXM1 identified in pediatric RMS genomic landscape study PMID:24436047

Cancer types (linked)

  • ODG — CCND2 marks the proliferative stem/progenitor apex of grade II oligodendroglioma; the cyclin switching pattern mirrors a normal developmental gradient from progenitor to differentiated neural cell types PMID:27806376.

Co-occurrence and mutual exclusivity

  • Co-expressed with ASCL1, CHD7, CD24, BOC, and SOX-family transcription factors in stem/progenitor cells; expression is inversely correlated with CCND1 and CCND3 (differentiated cell markers) PMID:27806376.

Therapeutic relevance

  • CCND2 expression marks the small cycling sub-population considered the most plausible therapeutic target in oligodendroglioma; CDK4/6 inhibitors could potentially target this compartment, though not directly tested in the corpus PMID:27806376.

Open questions

  • Whether targeting CDK4/6 (downstream effectors of cyclin D) would selectively eliminate the CCND2-high stem/progenitor pool without affecting the CCND1/CCND3-high differentiated compartment is not explored in the corpus.

Sources

This page was processed by crosslinker on 2026-05-09. - PMID:24120142

This page was processed by crosslinker on 2026-05-09. - PMID:24436047

This page was processed by crosslinker on 2026-05-09.