CFH
Overview
CFH (Complement Factor H) encodes a major regulator of the alternative complement pathway. In cancer, CFH has been identified as a recurrently homozygously deleted gene, suggesting a potential tumor-suppressive role in hepatocellular carcinoma.
Alterations observed in the corpus
- Recurrent homozygous deletion in hepatocellular carcinoma (HCC) PMID:25822088
Cancer types (linked)
- HCC: Recurrent homozygous deletion identified in a comprehensive genomic landscape study PMID:25822088
Co-occurrence and mutual exclusivity
- Co-deleted with IRF2 and PTPN3 as part of a set of recurrently homozygously deleted genes in HCC PMID:25822088
Therapeutic relevance
- No direct therapeutic targeting reported in the corpus.
Open questions
- Functional role of CFH loss in HCC tumorigenesis and whether it affects complement-mediated immune evasion remains to be established.
Sources
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