IRF2

Overview

IRF2 (Interferon Regulatory Factor 2) is a transcription factor that modulates interferon signaling and oxidative stress responses. In hepatocellular carcinoma (HCC), somatic mutations in IRF2 have been identified by next-generation sequencing as drivers linked to deregulated oxidative-stress signaling, alongside NFE2L2 and KEAP1.

Alterations observed in the corpus

  • Somatic mutations in HCC linked to oxidative-stress signaling dysregulation; identified as a driver gene by NGS in a 2014 HCC genomics review alongside NFE2L2 and KEAP1 PMID:24735922
  • IRF2 recurrently homozygously deleted in HCC (243-case European WES cohort); one of three genes with recurrent homozygous deletions highlighted (alongside CFH, PTPN3) PMID:25822088

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

  • Whether IRF2 mutations are mutually exclusive or co-occurring with NFE2L2/KEAP1 at the per-sample level in HCC requires larger cohort analysis.

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:25822088

This page was processed by crosslinker on 2026-05-14.