PTPN3
Overview
PTPN3 encodes a non-receptor protein tyrosine phosphatase. In hepatocellular carcinoma, PTPN3 was identified as a target of recurrent homozygous deletion, suggesting a tumor-suppressor role in liver cancer.
Alterations observed in the corpus
- In hepatocellular carcinoma (HCC), PTPN3 was identified as a target of recurrent homozygous deletion in the INSERM/TCGA 243-case exome cohort; listed alongside CFH and IRF2 as recurrently homozygously deleted. PMID:25822088
Cancer types (linked)
- HCC: recurrent homozygous deletion; candidate tumor suppressor in liver cancer. PMID:25822088
Co-occurrence and mutual exclusivity
- No specific co-occurrence or mutual exclusivity patterns reported in the corpus.
Therapeutic relevance
- No direct therapeutic relevance established in the corpus.
Open questions
- Functional role of PTPN3 loss in HCC pathogenesis requires experimental validation.
Sources
This page was processed by crosslinker on 2026-05-14.