COBL

Overview

COBL (Cordon-Bleu WH2 Repeat Protein) encodes an actin nucleation-promoting factor involved in cytoskeletal organization and neuronal morphogenesis. In small cell lung cancer, COBL has been identified as a candidate driver gene through whole-exome and whole-genome sequencing, though its functional role in SCLC pathogenesis lacks experimental validation.

Alterations observed in the corpus

  • Identified as a candidate driver gene in SCLC WES/WGS study (CLCGP, 29 tumors); listed among likely driver genes alongside TP53, RB1, PTEN, CREBBP, EP300, SLIT2, MLL, and EPHA7 based on mutation filtering criteria PMID:22941188

Cancer types (linked)

  • SCLC: COBL identified as candidate driver in a surgically resected SCLC cohort (29 tumors); functional characterization was not performed in the study PMID:22941188

Co-occurrence and mutual exclusivity

  • Co-identified with SLIT2 and EPHA7 as candidate driver genes in SCLC lacking functional validation at the time of publication PMID:22941188

Therapeutic relevance

  • No therapeutic relevance established in the corpus.

Open questions

  • Functional validation of COBL as a driver in SCLC is explicitly noted as lacking in the study; actin regulatory role may be relevant to metastatic potential but has not been tested PMID:22941188

Sources

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