COL1A1
Overview
COL1A1 encodes the alpha-1 chain of type I collagen, the most abundant fibrillar collagen in the extracellular matrix. In cancer genomics, COL1A1 is primarily used as a fibroblast lineage marker. In the context of normal skin melanocyte biology, COL1A1 expression in non-melanocyte populations (keratinocytes, fibroblasts) serves as a lineage confirmation marker to separate cell types in single-cell profiling.
Alterations observed in the corpus
- COL1A1 was used as a fibroblast lineage-confirmation marker (alongside LUM and S100A4) in spatial transcriptomic and single-cell profiling of normal human skin melanocytes across 31 donors; COL1A1 expression defined fibroblast populations and excluded them from the melanocyte analysis in the single-cell atlas (297 melanocytes from 58 biopsies) PMID:39975212.
- Expression positively correlated with stromal SEMA7A in GBC; co-expressed with SEMA7A and ACTA2 in ACTA2+ CAF subclusters by scRNA-seq (OEP00001237, 13 patients); upregulated as CAF activation marker under 16 kPa high-stiffness matrix PMID:24997986
Cancer types (linked)
- Normal skin (MEL adjacent) — COL1A1 used as a non-melanocyte lineage marker in the normal melanocyte atlas; no somatic alterations of COL1A1 were reported in this study PMID:39975212.
Co-occurrence and mutual exclusivity
- Not reported in this corpus.
Therapeutic relevance
- Not directly targeted therapeutically in this corpus.
Open questions
- No cancer-driver role for COL1A1 was identified in the citing paper; its utility is as a cell-type discrimination marker.
Sources
This page was processed by entity-page-writer on 2026-05-01. - PMID:24997986
This page was processed by wiki-cli on 2026-05-11.