LUM

Overview

LUM (Lumican) is an extracellular matrix proteoglycan belonging to the small leucine-rich proteoglycan (SLRP) family. It is a canonical marker of dermal fibroblasts and stromal cells. In single-cell and spatial transcriptomic studies of normal skin, LUM is used alongside COL1A1 and S100A4 to confirm fibroblast identity and exclude fibroblast contamination from melanocyte or keratinocyte analyses.

Alterations observed in the corpus

• Used as a fibroblast lineage-confirmation marker in a normal human skin atlas study profiling 297 single melanocytes from 31 donors with matched DNA/RNA sequencing and Xenium spatial validation; co-expressed with COL1A1 and S100A4 to define the fibroblast compartment. No somatic alterations reported. PMID:39975212

Cancer types (linked)

• No direct cancer-type association reported in the corpus. LUM is used as a cell-type anchor in non-lesional skin adjacent to melanoma to exclude stromal contamination from the melanocyte dataset. PMID:39975212

Co-occurrence and mutual exclusivity

• Co-expressed with COL1A1 and S100A4 in fibroblasts; mutually exclusive with melanocyte markers (PMEL, TYRP1, MLANA, MITF) and keratinocyte markers (KRT14, KRT17, KRT5). PMID:39975212

Therapeutic relevance

• No therapeutic relevance reported in the corpus.

Open questions

• None noted in the corpus.

Sources

• PMID:39975212

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