S100A4
Overview
S100A4 (S100 calcium-binding protein A4, also known as metastasin or FSP1) encodes a small calcium-binding protein of the S100 family implicated in cell motility, invasion, and metastasis. It is widely used as a fibroblast lineage marker in tissue atlases and is expressed in the tumor microenvironment where it can promote epithelial-to-mesenchymal transition.
Alterations observed in the corpus
- Fibroblast lineage-confirmation marker in normal skin atlas: S100A4 transcript is used alongside LUM and COL1A1 to confirm fibroblast identity in a normal human skin single-cell atlas profiling melanocyte subpopulations. No somatic driver alterations in S100A4 itself are reported in this study. PMID:39975212
Cancer types (linked)
- MEL / SKIN: S100A4 is referenced as a fibroblast marker in non-lesional skin adjacent to a melanoma patient specimen, establishing cell-type context rather than a tumor-driver role. PMID:39975212
Co-occurrence and mutual exclusivity
- Co-expressed with LUM and COL1A1 as part of the fibroblast identity gene set in normal skin atlas data. PMID:39975212
Therapeutic relevance
- No direct therapeutic finding reported in the current corpus. S100A4 has been studied as a pro-metastatic factor in multiple cancer types in the broader literature, but no corpus-specific claim is available.
Open questions
- Broader role of S100A4-expressing fibroblasts in the melanoma tumor microenvironment and their interaction with HighMut versus LowMut melanocyte subpopulations is not addressed by the current corpus. PMID:39975212
Sources
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