FGA
Overview
FGA (Fibrinogen Alpha Chain) encodes a component of fibrinogen, a hepatocyte-secreted clotting protein. In HCC genomics, FGA was newly highlighted as part of a hepatic-differentiation pathway recurrently mutated in tumors, suggesting loss of hepatocyte-specific function contributes to HCC pathogenesis.
Alterations observed in the corpus
- Hepatocyte-secreted protein gene recurrently mutated in HCC; part of the newly highlighted hepatic-differentiation pathway (34% pathway alteration) PMID:25822088
Cancer types (linked)
- HCC: Recurrently mutated alongside ALB and APOB as hepatocyte-secreted protein genes defining the hepatic-differentiation pathway in a comprehensive HCC genomic study PMID:25822088
Co-occurrence and mutual exclusivity
- Co-mutated with ALB and APOB as part of the hepatic-differentiation pathway (34% alteration) in HCC PMID:25822088
Therapeutic relevance
- No direct therapeutic targeting reported in the corpus.
Open questions
- Whether FGA mutations represent driver events or passenger mutations in the hepatic-differentiation context remains to be determined.
Sources
This page was processed by crosslinker on 2026-05-14.