MSRA
Overview
MSRA (methionine sulfoxide reductase A) encodes an enzyme that repairs oxidized methionine residues in proteins, protecting against oxidative stress. In cancer genomics, it has been identified as co-deleted within a recurrent homozygous-deletion peak on chromosome 8p23.1 in multiple myeloma.
Alterations observed in the corpus
- Co-deleted with BLK, PINX1, and SOX7 within the 8p23.1 homozygous-deletion peak in multiple myeloma (18 genes total); MM relevance not previously established for MSRA specifically PMID:24434212
Cancer types (linked)
- MM (Multiple Myeloma): Identified via co-deletion at 8p23.1; significance as a driver vs. passenger in this locus is unclear PMID:24434212
Co-occurrence and mutual exclusivity
- Co-deleted with BLK, PINX1, and SOX7 at the 8p23.1 deletion peak in MM PMID:24434212
Therapeutic relevance
- No targeted therapy established for MSRA deletion.
Open questions
- The functional relevance of MSRA deletion in MM pathogenesis remains unestablished.
Sources
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