PINX1
Overview
PINX1 (PIN2/TERF1-interacting telomerase inhibitor 1) encodes a telomerase inhibitor that regulates telomere length by binding TRF1 and suppressing telomerase activity. It is located on chromosome 8p23.1, a region recurrently homozygously deleted in multiple myeloma.
Alterations observed in the corpus
- Co-deleted with BLK, MSRA, and SOX7 within the 8p23.1 homozygous-deletion peak in multiple myeloma (18 genes total); MM relevance not previously established for PINX1 specifically PMID:24434212
Cancer types (linked)
- MM (Multiple Myeloma): Identified via co-deletion at 8p23.1; whether PINX1 loss drives telomere dysregulation in MM is uncharacterized PMID:24434212
Co-occurrence and mutual exclusivity
- Co-deleted with BLK, MSRA, and SOX7 at the 8p23.1 deletion peak in MM PMID:24434212
Therapeutic relevance
- No targeted therapy established for PINX1 deletion.
Open questions
- Whether PINX1 loss contributes to telomere instability in MM pathogenesis is unknown.
Sources
This page was processed by crosslinker on 2026-05-09.