SOX7

Overview

SOX7 encodes a member of the SOX (SRY-box) family of transcription factors involved in developmental regulation of vascular endothelium and hematopoiesis. Located at 8p23.1, SOX7 is subject to co-deletion with other genes in this region in multiple myeloma and other cancers; its tumor-suppressive role in hematologic malignancies is under investigation.

Alterations observed in the corpus

  • Co-deleted within the 8p23.1 homozygous-deletion peak (18 genes) in multiple myeloma; MM relevance not previously established at the time of reporting PMID:24434212

Cancer types (linked)

  • MM: co-deleted within the 8p23.1 homozygous-deletion peak in a comprehensive MM genomic analysis PMID:24434212

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic targeting reported in this corpus.

Open questions

  • Functional role of SOX7 co-deletion in MM pathogenesis is not established; driver versus passenger status at this locus is unclear.

Sources

This page was processed by crosslinker on 2026-05-09.