NTNG1
Overview
NTNG1 (Netrin-G1) encodes a GPI-anchored netrin family protein involved in axon guidance and synapse formation. In normal skin melanocyte biology, NTNG1 is identified as a transcriptomic LowMut marker of the neural-crest-lineage melanocyte subpopulation, which carries predominantly clock-like rather than UV-attributable somatic mutations.
Alterations observed in the corpus
- NTNG1 is a transcriptomic LowMut marker in normal human skin melanocytes; expressed in the low-UV-mutation-burden neural-crest-lineage subpopulation. Co-expressed with MYL9, MYLK, PALLD, VCAN, FBN1, ITM2A, TAGLN, SGCE, HACD1, SEMA3C, TCF4, DAAM2, and RGMB. PMID:39975212
- Axon-guidance pathway gene with a single-tumor somatic mutation in ACC PMID:26862087
Cancer types (linked)
- SKCM: The normal-tissue atlas was derived from non-lesional skin adjacent to a melanoma patient; NTNG1 expression marks LowMut melanocytes in the hair-follicle niche, which the authors propose as a UV-protected stem cell reservoir. No driver mutation role in melanoma is claimed. PMID:39975212
Co-occurrence and mutual exclusivity
- Co-expressed with MYLK, MYL9, PALLD, and other LowMut markers; mutually exclusive with HighMut pigmentation markers at the single-cell level in normal melanocytes. PMID:39975212
Therapeutic relevance
- No direct therapeutic link reported in the corpus. PMID:39975212
Open questions
- Whether NTNG1-expressing LowMut melanocytes are lineage-traced to the hair follicle (inferred from spatial co-occurrence, not direct tracking in humans) is unresolved. PMID:39975212
Sources
This page was processed by crosslinker on 2026-05-04. - PMID:26862087
This page was processed by wiki-cli on 2026-05-14.