SEMA3C
Overview
SEMA3C (semaphorin 3C) encodes a secreted member of the semaphorin family involved in axon guidance, angiogenesis, and neural-crest cell migration. Expression is prominent in neural-crest-derived lineages and has been associated with tumor invasion and therapy resistance in multiple cancer types.
Alterations observed in the corpus
- LowMut melanocyte subpopulation marker (neural-crest lineage): SEMA3C transcript expression characterizes the LowMut melanocyte subset in a normal human skin single-cell atlas — these cells carry fewer UV-attributable (SBS7) mutations and show clock-like (SBS1/SBS5) mutational patterns. No somatic driver mutations in SEMA3C are reported. PMID:39975212
Cancer types (linked)
- MEL / SKIN: SEMA3C expression aligns with neural-crest-lineage melanocyte states (WIMMS “AXL/Neuronal/Invasive”, Belote et al. “MSC”) that have been linked to melanoma invasiveness and drug resistance in external literature. The current paper establishes the normal skin context. PMID:39975212
Co-occurrence and mutual exclusivity
Therapeutic relevance
- No direct therapeutic finding reported in the current corpus. SEMA3C’s role in cancer invasion biology makes it a candidate of interest in melanoma progression studies.
Open questions
- Whether SEMA3C expression distinguishes melanoma subtypes (e.g., invasive/neural-crest-like vs. proliferative) and predicts therapy response remains an open question not addressed by the current corpus. PMID:39975212
Sources
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