PALLD

Overview

PALLD (Palladin) encodes an actin-associated protein that organizes the actin cytoskeleton and plays roles in cell morphology, migration, and adhesion. In normal skin biology, PALLD is identified as a transcriptomic LowMut marker of the neural-crest-lineage melanocyte subpopulation in a normal-skin single-cell genomics study.

Alterations observed in the corpus

• PALLD is a transcriptomic LowMut marker in normal human skin melanocytes; expressed in the low-UV-mutation-burden neural-crest-lineage subpopulation that aligns with the “AXL/Neuronal/Invasive” melanocyte state described in other atlases. Co-expressed with MYL9, MYLK, NTNG1, VCAN, FBN1, ITM2A, TAGLN, SGCE, HACD1, SEMA3C, TCF4, DAAM2, and RGMB. PMID:39975212

Cancer types (linked)

• SKCM: The atlas was generated from non-lesional skin adjacent to a melanoma patient; PALLD marks the LowMut melanocyte state proposed as a UV-protected hair-follicle-niche reservoir. No somatic driver role for PALLD in melanoma is claimed. PMID:39975212

Co-occurrence and mutual exclusivity

• Co-expressed with MYL9, MYLK, NTNG1, and other LowMut markers; mutually exclusive with HighMut pigmentation markers (HMOX1, ABCC2, MC1R, HERC2) at the single-cell level. PMID:39975212

Therapeutic relevance

• No direct therapeutic link reported in the corpus. PMID:39975212

Open questions

• PALLD’s role in mediating the invasive/migratory phenotype of the LowMut melanocyte state versus merely marking lineage identity is not addressed in this study. PMID:39975212

Sources

• PMID:39975212

This page was processed by crosslinker on 2026-05-04.