PIM2

Overview

PIM2 is a serine/threonine kinase in the PIM kinase family involved in cell survival, proliferation, and apoptosis resistance. In cancer genomics, PIM2 has been identified as a driver-gene cluster member in diffuse large B-cell lymphoma (DLBCL), particularly within B-cell development and transcription/translation functional groups.

Alterations observed in the corpus

PIM2 identified as a driver-gene cluster member across signaling, cell growth, B-cell development, and transcription/translation functional groups in a 1001-patient DLBCL genomic cohort (Duke, 2017) PMID:28985567.

Cancer types (linked)

DLBCL: Driver-gene cluster member identified via integrated genomic and CRISPR functional screening in 1001 patients PMID:28985567.

Co-occurrence and mutual exclusivity

Grouped with PIK3R1, BTK, CHD8, POU2F2, YY1, and H1-4 as driver-gene cluster members across B-cell signaling, growth, and transcription functional groups PMID:28985567.

Therapeutic relevance

As a PIM kinase family member and DLBCL driver, PIM2 may be relevant to PIM kinase inhibitor strategies in B-cell lymphoma.

Open questions

CRISPR essentiality data for PIM2 in DLBCL cell lines not separately reported; functional dependency vs. PIK3CD (which showed no CRISPR growth impairment) is unclear.

Sources

PMID:28985567

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