POU2F2

Overview

POU2F2 (also known as OCT2) is a POU-domain transcription factor critical for B-cell development and immunoglobulin gene expression. In cancer genomics, POU2F2 has been identified as a driver-gene cluster member in diffuse large B-cell lymphoma (DLBCL), grouped within B-cell development and transcription/translation functional groups.

Alterations observed in the corpus

  • POU2F2 identified as a driver-gene cluster member across signaling, cell growth, B-cell development, and transcription/translation functional groups in a 1001-patient DLBCL genomic cohort (Duke, 2017) PMID:28985567.

Cancer types (linked)

  • DLBCL: Driver-gene cluster member identified via integrated genomic and CRISPR functional screening in 1001 patients PMID:28985567.

Co-occurrence and mutual exclusivity

  • Grouped with PIK3R1, PIM2, BTK, CHD8, YY1, and H1-4 as driver-gene cluster members across B-cell signaling, growth, B-cell development, and transcription functional groups PMID:28985567.

Therapeutic relevance

  • As a transcription factor in B-cell development and a DLBCL driver, POU2F2 may be relevant to therapeutic strategies targeting OCT2/BOB1 co-activator signaling.

Open questions

  • Specific mutation spectrum and subtype enrichment (ABC vs. GCB DLBCL) for POU2F2 not detailed in the corpus.

Sources

This page was processed by crosslinker on 2026-05-15.