RBM12
Overview
RBM12 (RNA Binding Motif Protein 12) is an RNA-binding protein involved in mRNA processing and splicing regulation. In colorectal cancer genomics, RBM12 was newly nominated as a significantly mutated driver gene in a large prospective cohort study.
Alterations observed in the corpus
- Newly nominated as a significantly mutated gene (SMG) in non-hypermutated colorectal carcinoma (488 of 619 cases) in the 619-case WES cohort (NHS/HPFS); classified among RNA-processing driver genes (alongside RBM10). Among 90 significantly mutated genes found in non-hypermutated CRCs, 73 were new to CRC including RBM12. PMID:27149842
Cancer types (linked)
- COADREAD: RBM12 is a newly designated CRC driver gene via MutSigCV in the Giannakis et al. cohort. PMID:27149842
Co-occurrence and mutual exclusivity
- No specific co-occurrence or mutual exclusivity data reported for RBM12 in the current corpus.
Therapeutic relevance
- No direct therapeutic relevance reported in the current corpus.
Open questions
- The functional role of RBM12 mutations in colorectal cancer — whether they disrupt RNA splicing in an oncogenic or tumor-suppressive direction — is unresolved.
Sources
This page was processed by crosslinker on 2026-05-14.