RBX1
Overview
RBX1 (Ring-Box 1, also known as ROC1) is a RING domain protein and essential component of the SCF (SKP1-CUL1-F-box) E3 ubiquitin ligase complex. Copy number loss of SCF complex genes including RBX1 induces chromosomal instability (CIN) in colorectal cancer.
Alterations observed in the corpus
- Invariable core member of the SCF E3 ubiquitin ligase complex; copy number loss of SCF genes (SKP1, CUL1, RBX1) induces CIN in CRC PMID:36334560
Cancer types (linked)
- CRC: SCF complex gene copy number loss associated with CIN PMID:36334560
Co-occurrence and mutual exclusivity
- Copy number loss co-occurs with SKP1 and CUL1 loss in CRC PMID:36334560
Therapeutic relevance
Open questions
Sources
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