ROBO2

Overview

ROBO2 encodes roundabout guidance receptor 2, a SLIT ligand receptor involved in axon repulsion and cell migration. In pancreatic ductal adenocarcinoma, ROBO2 is mutated in approximately 5% of tumors and low ROBO2 expression associates with poor prognosis, implicating it as a candidate tumor suppressor within the SLIT-ROBO pathway.

Alterations observed in the corpus

  • Mutations in approximately 5% of pancreatic cancer tumors in WES of 142 ICGC tumors; low ROBO2 expression associates with poor prognosis in PDAC PMID:23103869

Cancer types (linked)

  • Pancreatic ductal adenocarcinoma (PAAD): mutated in ~5% of tumors; low expression is a poor prognostic biomarker PMID:23103869

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • ROBO2 expression level may serve as a prognostic biomarker in PDAC; low ROBO2 expression may identify patients with poor prognosis PMID:23103869

Open questions

  • Functional validation of ROBO2 mutations as true drivers in PDAC is incomplete; the prognostic association of low expression requires prospective validation PMID:23103869

Sources

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