RTTN
Overview
RTTN (Rotatin) encodes a centrosomal protein required for ciliogenesis and left-right body axis formation. In neuroblastoma, RTTN is a defining marker of the novel postnatal human adrenal progenitor cluster hC1, and its expression defines the initial undifferentiated state in the adrenal differentiation trajectory.
Alterations observed in the corpus
- RTTN is a significantly over-expressed marker gene of the novel postnatal human adrenal progenitor cluster hC1 (FDR <0.01, Welch’s t-test on 1,322 nuclei). RNA velocity and pseudotime analyses position RTTN expression at the apex of the adrenal differentiation trajectory: cells transition from an undifferentiated RTTN+ state through noradrenergic DBH+ intermediates to an adrenergic PNMT+ chromaffin end-state. RTTN is part of the shared gene program between hC1 (normal postnatal progenitor) and nC3 (high-risk neuroblastoma undifferentiated cluster). PMID:34493726
Cancer types (linked)
- NBL — RTTN marks the undifferentiated apex state in both normal postnatal adrenal (hC1) and high-risk neuroblastoma (nC3) transcriptional hierarchies. Its co-expression with other progenitor markers supports the hypothesis that high-risk neuroblastoma cells share identity with a unique postnatal human progenitor. PMID:34493726
Co-occurrence and mutual exclusivity
Therapeutic relevance
- No direct therapeutic targeting is reported in the corpus.
Open questions
- Whether RTTN plays a functional role in the proliferative progenitor state or is a passenger of this transcriptional program is not addressed. PMID:34493726
Sources
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